BUY DOXYCYCLINE ONLINE
The active component is doxycycline, a semi-synthetic antimicrobial substance of the tetracycline group. This drug has a mechanism that is associated with the influence on the synthesis of the very proteins in the cell of sensitive microorganisms.
Active Ingredient: Doxycycline
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What is Doxycycline
Doxycycline is a bactericidal, semi-synthetic antimicrobial medicine that belongs to tetracyclines. The principle of its action is associated with a slowdown (stop) of protein synthesis in sensitive microorganisms.
The active component of the drug in the digestive tract is well absorbed. The absorption of the antibiotic is not dependent on food intake, the peak concentration of doxycycline is observed 2 hours after taking the drug. Doxycycline, among other tetracyclines, penetrates better into the tissues of the body, due to its high lipophilicity. About 80-90% of the antibiotic binds almost completely to plasma proteins. The main half-life of doxycycline is about 12-18 hours with a single use and up to 22-24 hours with normal regular antibiotic intake.
Dosage and method of using Doxycycline
Doxycycline is for oral use. It is recommended to take the tablets whole with a large amount of liquid. The antibiotic should be taken during meals, do not drink the drug with milk or dairy products. It is not recommended to take the drug immediately before bedtime.
The standard scheme of drug therapy:
Adults whose body weight exceeds 70kg are recommended to prescribe 200mg of the drug per day during the entire course of treatment. The daily dose of the drug is allowed to be taken in one dose or in two doses with an interval of 12 hours.
Adults and adolescents who have a weight of 50 to 70kg are recommended to prescribe 200mg of doxycycline on the 1st day of treatment, after which it is recommended to change the intake to 100mg of antibiotic per day.
Children (patients) who are older than eight years old and weighing less than 50kg, it is best to take a dose of 4mg/kg of the patient’s weight for the first time of treatment, after which they should switch to a dose of 2mg/kg of the patient’s weight per day. For especially severe infections, it is recommended to take a dose of 4mg/kg of the patient’s weight per day throughout the course.
The duration of treatment is usually from 7 to 14 days, treatment must be continued for at least three days after the symptoms of the disease have disappeared.
In such infections that caused staphylococci (beta hemolytic), the duration of treatment should be at least ten days.
Special treatment regimens:
Adults with diseases that are transmitted by ticks are recommended to prescribe 200mg of doxycycline per day for 10-20 days;
Women with acute gonorrhea, as well as men with acute urethritis, which is caused by gonococci, it is recommended that 200mg of doxycycline per day for seven days;
For men suffering from infectious diseases that relate to the genitourinary system with impaired fertilization of an unknown etiology, it is recommended that 200mg be given per day for 28 days (simultaneous treatment of partners is necessary);
For infections caused by chlamydia and gonococcus, it is recommended the appointment of 200mg per day for ten days;
In acute non-specific diseases of the genital organs in women, it is recommended to prescribe 200mg per day for ten to fourteen days (in combination with other drugs);
Adults with syphilis are recommended the appointment of 300mg of doxycycline per day for at least ten days;
With dermatological diseases, it is recommended that 100mg per day for 1-3 weeks.
With prolonged therapy with Doxycycline, it is recommended to monitor the function of the liver and kidneys.
Doxycycline side effects
During therapy with Doxycycline in patients, the development of such undesirable effects is possible:
1. From the side of the heart, blood vessels and hemopoietic system: tachycardia, leukopenia, leukocytosis, anemia, thrombocytopenia, coagulation disorders, lymphadenopathy. In isolated cases, the presence of toxic granularity in granulocytes and atypical lymphocytes was also noted.
2. From the central nervous system: paresthesia, decreased visual acuity, increased intracranial pressure, excessive excitability, generalized convulsions.
3. From the gastrointestinal tract and liver: heartburn, flatulence, nausea, vomiting, impaired stool, stomatitis, glossitis, discoloration of the teeth. It is also possible the development of pseudomembranous enterocolitis, which may require discontinuation of the drug doxycycline.
4. From the urinary system: hematuria, impaired renal function (function), nephritis (interstitial), anuria.
Allergic reactions: photosensitivity, skin itching, urticaria, bronchospasm, erythema, Lyell syndrome, Quincke edema, Stevens-Johnson syndrome, anaphylactic shock. It is also possible the development of a reaction that is accompanied by hyperthermia, headache and arthralgia.
Others: pain in muscles and joints, impaired taste and smell, vaginal and oral candidiasis, itching in the anus, hypertrichosis. In addition, doxycycline may increase plasma residual nitrogen levels.
With the development of undesirable effects, you should discontinue the drug and consult a doctor as soon as possible, who will decide on the possibility of further use of doxycycline or prescribe alternative therapy.
Doxycycline is contraindicated in people with individual sensitivity to doxycycline and other tetracycline drugs, as well as excipients of the drug.
The antibiotic is contraindicated in patients with severe renal and hepatic impairment.
Doxycycline is not used for the treatment of children (patients) under eight years of age, because the use of this drug during the development of teeth can have an irreversible effect on the color of tooth enamel.
Caution is necessary when prescribing an antibiotic to patients suffering from arrhythmias, as well as to patients who are exposed to ultraviolet rays (since the risk of developing photosensitization should not be exposed to sunlight for a long time, as well as visiting a solarium during doxycycline therapy).
Doxycycline is prescribed with caution to people who operate unsafe mechanisms and drive a car.
An overdose of doxycycline in patients showed the development of impaired liver function, as well as undesirable effects from the gastrointestinal tract.
There is no specific antidote. With intoxication with doxycycline, gastric lavage and symptomatic agents are prescribed.
In case of an overdose, it is also possible to prescribe calcium preparations, since doxycycline forms complexes (chelate) with calcium ions.
Conducting dialysis (peritoneal) and hemodialysis for poisoning is ineffective.